If you're using Ubuntu in Linux, known issues between Chrome and Ubuntu may be the cause of your audio issues. One way to fix this problem is to "force" the sound to "restart" after your initial installation of Chrome.
After your initial installation of Chrome, open your terminal and enter the following code:
sudo apt-get remove --purge alsa-base pulseaudio indicator-sound
sudo apt-get install alsa-base pulseaudio indicator-sound
sudo alsa force-reload
For more help, check out these topics in the Google Chrome Help Forum:
Sound issues in Google Chrome, on Ubuntu
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